Human Beta Defensin-3 Ignites in Oral Cancer Growth

Recently, Science Daily posted an article with updates on advancements in oral cancer research.  According to the article, early detection could save upwards of 40,000 people daily.  Below is an excerpt of this groundbreaking news:

“Case Western Reserve University School of Dental Medicine researchers discovered a biomarker, called human beta defensin-3 (hBD-3), which may serve as an early warning. The defensin is present in all oral cancers and associated with the early stages of oral cancer.

‘Using the biomarker to detect oral cancer holds potential for saving lives when the cancer is most curable. Annually some 10,000 people die from this cancer,’ said Ge Jin, assistant professor of biological sciences at the dental school.

He led the study, which appears in the online journal PLoS ONE, published by the Public Library of Science.

Oral cancer first appears as white or red lesions in the mouth, the same as noncancerous lesions.

Often, the lesions are not biopsied, and cancer is not discovered until it becomes apparent in its later stages, when it has metastasized to other organs. Such a late-stage diagnosis is generally fatal and can result in costly surgeries and treatments or disfigurement that may include removing parts of the tongue, jaw and cheek. All this can be avoided with early removal of the lesion.”

Click here for the complete Science Daily article regarding the role of hBDs in oral health and the potential of using this biomarker to detect oral cancer early.


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