SIBLING Proteins and Oral Cancer Treatment

Recently Science Daily posted an article entitled: SIBLING Proteins May Predict Oral Cancer. This article is interesting as it offers greater hope in the advancement of oral cancer treatment.  A SIBLING stands for Small Integrin-Binding Ligand N-linked Glycoproteins.

“Several years ago we discovered that three SIBLINGs — osteopontin, bone sialoprotein and dentin sialophosphoprotein — were expressed at significantly high levels in oral cancers,” said Dr. Kalu Ogbureke, an oral and maxillofacial pathologist in the MCG School of Dentistry. “Following that discovery, we began to research the potential role of SIBLINGs in oral lesions before they become invasive cancers.”

Up to this point it’s been so difficult to determine which cells were precancerous that early oral cancer treatment has been difficult.  With the research on SIBLING proteins, there is hope for better results for treatment.

Dr. Ogbureke’s next step is to design a multi-center study that incorporates oral cancer risk factors, such as smoking and alcohol consumption, to further investigate their relationship with SIBLING protein expression.


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